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Medicinal Chemistry Senior Principal Research Scientist

Vertex PharmaceuticalsSan Diego, CA

$164,400–246,600/yr

Posted Oct 16, 2026

What you’d do

Lead medicinal chemistry strategy for small-molecule discovery programs, designing and guiding synthesis of compounds to optimize potency, selectivity, pharmacokinetics, and developability. On-site role with about 75% of time spent in the lab. Found on the employer's careers page on Oct 17, 2026. Apply through the link.

You’ll need

  • Deep expertise in small-molecule drug discovery
  • Medicinal chemistry
  • Organic synthesis
  • Lead optimization and SAR analysis
  • On-site with ~75% lab time

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